Description
- Inclusion criteria of Cohort 1- Newborn:
- * Subjects aged 1-2 days
- * Subjects with gestational age 37-42 weeks
- * Subjects with stable clinical status (admitted to normal newborn nursery)
- Inclusion criteria of Cohort 2 - Older children:
- • Subjects aged 0-18 years
- Inclusion criteria of Cohort 3 - Diseased children:
- Subjects (no age limit) with ANY phenotype as below:
- * Confirmed metabolic or genetic diseases
- * Suspected metabolic or genetic diseases
- * Episodic metabolic decompensation (e.g. hypoglycemia, hyperammonemia, metabolic acidosis)
- * Developmental regression
- * Major congenital malformation
- * Other unexplained symptoms of potential genetic origin
- Exclusion criteria of Cohort 1 - Newborn:
- * Subjects with gestational age \<37 weeks or \>42 weeks
- * Subjects with overt signs of metabolic dysfunction, distress or genetic diseases including hypoglycemia, hyperglycemia, sepsis/shock, hypoxemia, or major congenital malformation
- * Subjects with mothers whose pregnancies were complicated by gestational diabetes, gestational hyperglycemia, gestational hypertension, preeclampsia, or any other major disorders.
- Exclusion criteria of Cohort 2 - Older children:
- * Subjects with confirmed metabolic or genetic diseases
- * Subjects with suspected metabolic or genetic diseases
- * Subjects with episodic metabolic decompensation (e.g. hypoglycemia, hyperammonemia, metabolic acidosis)
- * Subjects with developmental regression
- * Subjects with major congenital malformation
- Exclusion criteria of Cohort 3 - Diseased children No.
Ages Eligible for Study:
1 Day to N/A (CHILD, ADULT, OLDER_ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
No