Gene Expression Changes In Young and Geriatric Skin
This study does not involve any particular diagnosis. The goal of this research study is to explore the effects of artificial sunlight (ultraviolet B radiation; UVB) on the skin of young adults versus geriatric adults. Sunlight exerts many effects on the body. There is evidence that in response to ultraviolet B radiation (UVB), which are the burning rays of sunlight, young adult skin responds differently than geriatric skin. In fact, researchers feel that this difference in how the skin reacts to UVB is why skin cancers are found in older skin. Researchers believe that a major difference between young adult and geriatric skin is that young skin has a lot of a protein called insulin-like growth factor-1 (IGF-1), whereas geriatric skin has very little. The current study will test how young adult versus geriatric skin responds to UVB, and if geriatric skin treated with an injection of small amount of IGF-1 drug will then act like young skin.
Conditions:
🦠 UVB Phototherapy Burn 🦠 Insulin-like Growth Factor 1 🦠 Aging
🗓️ Study Start (Actual) 6 September 2019
🗓️ Primary Completion (Estimated) December 2025
✅ Study Completion (Estimated) December 2025
👥 Enrollment (Estimated) 24
🔬 Study Type INTERVENTIONAL
📊 Phase EARLY_PHASE1
Locations:
📍 Fairborn, Ohio, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • * Male/Female
    • * White skin (Fitzpatrick types I and II)
    • * Age 21-30 or 65 and older
    • * Able to comprehend procedures/risks

    Exclusion Criteria:

    • * Known photosensitivity
    • * Currently on photosensitizing medications
    • * Diabetes Mellitus
    • * History of abnormal scarring
    • * History of skin infections
    • * Known allergy to lidocaine local anesthetic
    • * Pregnancy or nursing
    • * Other serious health issues
Ages Eligible for Study: 21 Years to N/A (ADULT, OLDER_ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: Yes

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 26 April 2019
  • First Submitted that Met QC Criteria 26 April 2019
  • First Posted 30 April 2019

Study Record Updates

  • Last Update Submitted that Met QC Criteria 9 January 2024
  • Last Update Posted 10 January 2024
  • Last Verified January 2024