Description
Inclusion Criteria:
- 1. Confirmed CF diagnosis
- 2. Ages 18 years and older
- 3. Baseline estimated daily total added sugar intake \>16 tsp, as estimated from the Dietary Screener Questionnaire (DSQ).
Exclusion Criteria:
- 1. Nocturnal tube feeds
- 2. BMI \<18.5 kg/m2
- 3. Life expectancy \< 12 months
- 4. Confirmed diagnosis of CFRD
- 5. Screening OGTT showing fasting hyperglycemia (≥126 mg/dL)
- 6. Chronic steroid use
- 7. Current pregnancy or lactation
- 8. Inability/unwillingness to consume the majority of foods on the menu during the study period
- 9. MRI-incompatible metal that cannot be removed for testing
- 10. Uncontrolled exocrine pancreatic insufficiency/malabsorption
- 11. Clinically instability, defined as no changes in medical regimen (including medications and pulmonary exacerbations) for at least 21 days prior to study visit
- 12. Initiation of CFTR modulator within previous 8 weeks OR unstable changes in weight and lung function due to CFTR modulator use
- 13. Actively trying to gain or lose weight
- 14. Any food allergies or intolerances that cannot be accommodated
- 15. Any medical condition deemed by the a study physician or PI that may preclude completion of the study or interfere with primary end points.
Ages Eligible for Study:
18 Years to N/A (ADULT, OLDER_ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
No