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Exercise Training and Fat Metabolism in Postmenopausal Women
Adipose tissue turnover plays a critical role in body weight maintenance, and obesity is underscored by the dysregulated balance between fat breakdown and synthesis. Although there are clear health-related benefits of physical activity, little is known about how resistance exercise, as opposed to endurance exercise, can reduce the risk of metabolic disorders, particularly in women. The goal of the proposed study is to investigate the effectiveness of resistance training to improve basal and stimulated fat metabolism in postmenopausal women with obesity and pre-diabetes, potentially serving as a viable and practical approach to prevent the onset of type 2 diabetes.
Conditions:
🦠 Postmenopausal Symptoms 🦠 Obesity 🦠 Prediabetic State
🗓️ Study Start (Actual) 20 May 2022
🗓️ Primary Completion (Estimated) May 2026
✅ Study Completion (Estimated) December 2026
👥 Enrollment (Estimated) 120
🔬 Study Type INTERVENTIONAL
📊 Phase NA
Locations:
📍 Tallahassee, Florida, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • * Women
    • * Postmenopausal (50-70 yrs.)
    • * Obese (BMI 30-39.9 kg/m2)
    • * Prediabetes (HbA1c 5.7 - 6.4% or fasting blood glucose 100 to 125 mg/dL, or 2hr OGTT blood glucose 140 to 199 mg/dL)
    • * Sedentary (not performing purposeful exercise training more than 20 minutes per day twice a week)
    • * Non-smokers
    • * No hormone replacement therapy for at least the past two years.

    Exclusion Criteria:

    • * Engaging in purposeful resistance training or endurance training (\> 20min/day, \> 2 days/week)
    • * Resting blood pressure above 140 mmHg systolic or 90 mmHg diastolic
    • * Type 1 or type 2 diabetes
    • * Medical problems in which exercise is contraindicated, such as chronic infections
    • * History of, or currently presentation with, cancer, cardiovascular or respiratory disease
    • * Uncontrolled thyroid dysfunction, liver or renal dysfunction
    • * Taking any medication affecting lipid metabolism
    • * Musculoskeletal disease or injury that would otherwise prevent engagement in resistance and endurance training
    • * Smokers and those with diagnosed eating disorders
Ages Eligible for Study: 50 Years to 70 Years (ADULT, OLDER_ADULT)
Sexes Eligible for Study: FEMALE
Accepts Healthy Volunteers: No

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 4 April 2022
  • First Submitted that Met QC Criteria 22 April 2022
  • First Posted 28 April 2022

Study Record Updates

  • Last Update Submitted that Met QC Criteria 25 July 2023
  • Last Update Posted 27 July 2023
  • Last Verified July 2023
I'm interested ...!!