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Exercise-Induced Gut Permeability in Normal-weight Obesity
Exercise acutely increases gut permeability and inflammation, even in healthy populations. However, whether this response differs in groups at-risk for CVD that present with low-grade inflammation (e.g., normal-weight obesity) has yet to be examined. The investigators aim to measure serum indicators of gut permeability in those with normal-weight obesity pre- and post-short, intense exercise and sustained, moderate exercise
Conditions:
🦠 Normal-weight Obesity 🦠 Obesity
🗓️ Study Start (Actual) 10 January 2023
🗓️ Primary Completion (Estimated) 1 August 2023
✅ Study Completion (Estimated) 1 August 2023
👥 Enrollment (Estimated) 30
🔬 Study Type INTERVENTIONAL
📊 Phase NA
Locations:
📍 Stillwater, Oklahoma, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • Control group: normal BMI, body fat percentage \< 25% (male) or \< 35% (female)
    • Normal-weight obesity: normal BMI, body fat percentage \> 25% (male) or \> 35% (female)
    • Overt obesity: BMI in obesity range, body fat percentage \> 25% (male) or \> 35% (female)

    Exclusion Criteria:

    • * Presence of pacemaker
    • * Pregnant
    • * Postmenopausal status
    • * History of chronically using of tobacco products, illicit drugs, anti-inflammatory drugs (e.g., NSAIDs), lipid lowering drugs
    • * Recent use of antibiotics (\< 6 weeks) and NSAIDs (\< 3 days)
    • * Established cardiometabolic disease (e.g., cardiovascular disease, type 2 diabetes) diseases inflammatory in nature (e.g., rheumatoid arthritis, inflammatory bowel disease), and/or diagnosed irritable bowel syndrome.
Ages Eligible for Study: 18 Years to 50 Years (ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: Yes

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 4 May 2023
  • First Submitted that Met QC Criteria 2 June 2023
  • First Posted 5 June 2023

Study Record Updates

  • Last Update Submitted that Met QC Criteria 2 June 2023
  • Last Update Posted 5 June 2023
  • Last Verified June 2023
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