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Exercise Effects on Adipose Tissue Structure and Function
Participants will be randomized into one of two different experimental groups: 1) Exercise group and 2) No exercise (control group). Subject participation in the study will involve a series of metabolic tests before and after participants undergo a 10% weight loss program (with or without exercise training depending on group randomization). After completing this weight loss portion of the study, participants will then be required to adhere to a high calorie diet program to regain half of the weight the participant lost - followed by the same series of metabolic tests.
Conditions:
🦠 Obesity 🦠 Metabolic Syndrome 🦠 Metabolic Disease 🦠 Insulin Resistance 🦠 Weight Loss 🦠 Weight Gain
🗓️ Study Start (Actual) 1 March 2021
🗓️ Primary Completion (Estimated) 1 March 2026
✅ Study Completion (Estimated) 1 March 2030
👥 Enrollment (Estimated) 46
🔬 Study Type INTERVENTIONAL
📊 Phase NA
Locations:
📍 Ann Arbor, Michigan, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • * Age: 18-40
    • * Body Mass Index: 27-45 kg/m2
    • * No regularly planned exercise/physical activity for at least 6 months
    • * Women must have regularly occurring menses and must be premenopausal

    Exclusion Criteria:

    • * Evidence/history of cardiovascular or metabolic disease
    • * Medications known to affect lipid or glucose metabolism, or inflammation
    • * Weight instability ≥ ± 6 pounds in the last 3 months
    • * Tobacco or e-cigarette users
    • * Women must not be pregnant or actively lactating
Ages Eligible for Study: 18 Years to 40 Years (ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 19 March 2021
  • First Submitted that Met QC Criteria 19 March 2021
  • First Posted 23 March 2021

Study Record Updates

  • Last Update Submitted that Met QC Criteria 19 June 2024
  • Last Update Posted 21 June 2024
  • Last Verified June 2024
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