Inclusion Criteria:

• 1. Male or female subjects \> 18 years of age.
• 2. Subject has a skin condition amenable to cryosurgical treatment including, for example, psoriasis, atopic dermatitis, acne, rosacea, and melasma.
• 3. Subject is willing to have skin exposed to cooling with the Dermal Cooling System.
• 4. Subject is willing to have digital photographs taken of the treatment area and agrees to use of photographs for presentation, educational, or marketing purposes.
• 5. Subject is willing to cover treated area or have very limited sun exposure and use an approved sunscreen of SPF 50 or higher on the treated area for the duration of the study, including the follow-up period, if requested.
• 6. Subject has read and signed a written informed consent form.
• 7. Subject is willing to comply with adjuvant topical regimen, as applicable.
• 8. Subject agrees not to undergo any other procedure(s) in the treatment area during the study.

Exclusion Criteria:

• 1. Dermatological conditions (e.g. vitiligo, open wounds, infection, pre-cancerous or malignant lesions) in the location of the treatment sites that would, in the professional opinion of the investigator, potentially pose an increased risk to the subject
• 2. Use of Accutane within the previous 6 months
• 3. History of melanoma
• 4. Subject is pregnant or intending to become pregnant during the study period
• 5. Subject is lactating or has been lactating in the past 6 months
• 6. Known history of illness or adverse reaction to cold insult (e.g., cryoglobulinemia, cold urticaria, paroxysmal cold hemoglobinuria, Reynaud's disease.
• 7. History of abnormal wound healing or abnormal scarring
• 8. Inability or unwillingness to comply with the study requirements.
• 9. Current enrollment in a clinical study of any other unapproved investigational drug or device.
• 10. Any other condition or laboratory value that would, in the professional opinion of the investigator, potentially affect response or participation in this clinical study, or would pose an unacceptable risk to the subject.