Description
Inclusion Criteria:
- 1. age ≥18 years;
- 2. diagnosis of end-stage kidney disease requiring dialysis, and
- 3. ability to provide informed consent.
Exclusion Criteria:
- 1. systolic blood pressure \<100 mm Hg (pre-dialysis for HD patients)
- 2. two or more episodes of urinary tract infection within the last 12 months
- 3. history of urinary retention or urinary tract obstruction
- 4. liver cirrhosis
- 5. advanced heart failure requiring heart assist device or inotropic support
- 6. heart or liver transplant recipient
- 7. major surgery performed within the last 3 months ("major" per the investigator's assessment)
- 8. major surgery scheduled within 3 months after screening ("major" per the investigator's assessment)
- 9. active cancer
- 10. pregnant or lactating women
- 11. known allergy or hypersensitivity to any SGLT2 inhibitors
- 12. history of ketoacidosis during the last 12 months
- 13. any other medical condition considered unappropriated by their nephrologists or a study physician (i.e., cachexia, short life expectancy, or uncontrolled personality/phycological disorder).
Ages Eligible for Study:
18 Years to N/A (ADULT, OLDER_ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
No