Electrographic Seizure Management and Neurobehavioral Outcomes in Critically Ill Children
Electrographic seizures are common in critically ill patients leading to increased use of resource-intense continuous EEG monitoring for seizure identification and management. When identified, electrographic seizures are generally treated with anti-seizure medications, but there are very limited data available regarding optimal treatment in terms of the efficacy or safety of specific anti-seizure medications or overall management strategies. This is a single-center prospective observational study. The investigators aim to: (1) track critically ill patients undergoing clinically indicated EEG monitoring and seizure management to identify risk factors for electrographic seizures, (2) create prediction models guiding EEG monitoring resources to the patients at highest risk for seizures, and (3) evaluate our current management strategy in terms of safety.
Conditions:
🦠 Seizures
🗓️ Study Start (Actual) 13 March 2017
🗓️ Primary Completion (Estimated) 1 January 2027
✅ Study Completion (Estimated) 1 January 2027
👥 Enrollment (Estimated) 2500
🔬 Study Type OBSERVATIONAL
📊 Phase N/A
Locations:
📍 Philadelphia, Pennsylvania, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • 1. Care in the Children's Hospital of Philadelphia Pediatric ICU.
    • 2. Clinically indicated continuous EEG monitoring.
    • 3. Age \> 1 month to 18 years.

    Exclusion Criteria:

    • 1. Admitted for Phase 2 (intracranial) EEG monitoring.
    • 2. Intensivist expects to discontinue technological support in the next two days given underlying medical or neurological problems.
Ages Eligible for Study: 1 Month to 18 Years (CHILD, ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 24 January 2018
  • First Submitted that Met QC Criteria 31 January 2018
  • First Posted 1 February 2018

Study Record Updates

  • Last Update Submitted that Met QC Criteria 29 January 2024
  • Last Update Posted 31 January 2024
  • Last Verified January 2024