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Effects of Obesity and Intensity of Exercise on Ghrelin Levels
This study is investigating the effect of different intensities of exercise on levels of the hormone, ghrelin. In addition, we will be examining the relationship between any exercise induced changes in ghrelin and insulin sensitivity, obesity, and vascular function.
Conditions:
🦠 Obesity 🦠 Insulin Resistance 🦠 Cardiovascular Risk Factor
🗓️ Study Start (Actual) 14 October 2020
🗓️ Primary Completion (Estimated) July 2024
✅ Study Completion (Estimated) July 2024
👥 Enrollment (Estimated) 80
🔬 Study Type INTERVENTIONAL
📊 Phase NA
Locations:
📍 Charlottesville, Virginia, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • * 18-55 years of age
    • * BMI between 18-40 kg/m2
    • * Untrained (reports less than 2 days/week of exercise)
    • * Weight stable (no significant loss/gain of more than 3kg in the past 3 months)
    • * Females must be premenopausal and report normal menstrual cycles

    Exclusion Criteria:

    • * History of diabetes, gastrointestinal disease, or endocrine disorder
    • * Smoking (must have quit at least 6 months prior)
    • * Disordered eating
    • * Females currently pregnant or undergoing fertility treatments
    • * The following medications (due to their effect on insulin sensitivity ,endothelial function and/or ghrelin secretion): Synthetic growth hormone, metformin, synthetic insulin, sulfonylureas, meglitinides, Thiazolidinediones, DPP-4 inhibitors, GLP-1 receptor agonists, SGLT2 inhibitors , biguanides, alpha-glucosidase inhibitors, phosphodiesterase inhibitors, beta-blockers, alpha-blockers, ACE-inhibitors, ARB's, fibrates, glucocorticoids, olanzapine
Ages Eligible for Study: 18 Years to 55 Years (ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: Yes

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 1 October 2020
  • First Submitted that Met QC Criteria 8 October 2020
  • First Posted 9 October 2020

Study Record Updates

  • Last Update Submitted that Met QC Criteria 8 May 2023
  • Last Update Posted 10 May 2023
  • Last Verified May 2023
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