Description
Inclusion Criteria:
- * Aged 18-59 years
- * Assigned male sex or female sex at birth
- * In good general health
- * Not currently taking doxycycline or other tetracycline-derived antibiotics and no plans to initiate during the study
- * For HIV-positive people, on stable antiretroviral therapy with an undetectable viral load and CD4 count\> 300ul/ml
- * Willing to use condoms consistently for the duration of the study
- * Able to provide informed consent
- * No plans for relocation in the next 4 months
- * Not pregnant and does not plan on getting pregnant for the duration of the study
- * Willing to undergo peripheral blood, urine, rectal or vaginal secretion collection, and a rectal or vaginal and cervical biopsy procedure
- * Willing to use study products as directed
Exclusion Criteria:
- * Current or chronic history of liver disease
- * Continued need for, or use during the 90 days before enrollment, of the following medications:
- 1. Systemic immunomodulatory agents
- 2. Supraphysiologic doses of steroids (short course steroids less than 7 days duration, allowable at the discretion of the investigators)
- 3. Chemotherapy or radiation for treatment of malignancy
- 4. Experimental medications, vaccines, or biologicals
- * Intent to use doxycycline or other tetracycline-derived antibiotics during the study, outside of the study procedures
- * Any other clinical condition or prior therapy that, in the opinion of the investigator, would make the patient unsuitable for the study or unable to comply with the study requirements
- * Known allergic reaction to study drugs.
- * Significant laboratory abnormalities at baseline visit for rectal biopsies, including but not limited to:
- 1. Hgb ≤ 10 g/dL
- 2. PTT \> 1.5x ULN or INR \> 1.5x ULN
- 3. Platelet count \<100,000
Ages Eligible for Study:
18 Years to 59 Years (ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Yes