• Inclusion Criteria
• 1. Diagnosis of rhabdomyolysis defined as creatine kinase\> 5000 with trauma excluded
• 2. Ability of parents/patients to understand and the willingness to sign a written informed consent document.
• 3. Patients ages 12 and older will sign written assent

Exclusion Criteria:

• * Already taking systemic steroids.
• * Inability to comply with study instructions.
• * Uncontrolled intercurrent illness or psychiatric illness/social situations that would limit compliance with study requirements.
• * Pregnant women.
• o A urine pregnancy test will be performed for women of child-bearing potential.
• * Below gestational age of 40 weeks
• * Allergy to fluconazole, clotrimazole or nystatin.
• * Cannot tolerate PO medications