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Detection of Brown Adipose Tissue by Magnetic Resonance Imaging
The primary goal of this study is to assess the accuracy of conventional fat fraction proton MRI for the detection of Brown Adipose Tissue (BAT) in healthy subjects using 18F-2-fluoro-2-deoxy-D-glucosefluorodeoxyglucose -PET as gold standard. In this pilot study, MRI and PET imaging of BAT of healthy adult volunteers will be performed on a combined PET/MRI scanner under mild cold condition.
Conditions:
🦠 Obesity
🗓️ Study Start (Actual) September 2014
🗓️ Primary Completion (Estimated) October 2024
✅ Study Completion (Estimated) October 2025
👥 Enrollment (Estimated) 40
🔬 Study Type OBSERVATIONAL
📊 Phase N/A
Locations:
📍 Chapel Hill, North Carolina, United States
📍 Chapel Hill, North Carolina, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • * Each subject must be fully informed and have signed consent.
    • * BMI \< 34
    • * Normal neurological and psychological development / able to give consent
    • * Willingness to participate in this study

    Exclusion Criteria:

    • * Subjects less than 18 years of age
    • * Severe claustrophobia
    • * Women who are pregnant, nursing an infant or planning to become pregnant in the next 30 days
    • * People who have a condition that makes MRI unsafe for them (for example, cardiac pacemaker, epicardial pacemaker leads, cochlear implants, metal aneurysm clip, iron filings in your eyes or metal halo devices)
    • * Have had radiation therapy or chemotherapy in the 2 months prior to PET scan
    • * Subjects are taking medications that may interfere with BAT detection
Ages Eligible for Study: 18 Years to N/A (ADULT, OLDER_ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: Yes

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 9 September 2014
  • First Submitted that Met QC Criteria 9 September 2014
  • First Posted 11 September 2014

Study Record Updates

  • Last Update Submitted that Met QC Criteria 24 July 2023
  • Last Update Posted 27 July 2023
  • Last Verified July 2023
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