Cortical Excitability in Cyclic Vomiting Syndrome

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This exploratory study will determine if there are differences in cortical excitability between patients suffering from cyclic vomiting syndrome (CVS) and healthy control subjects, as assessed by a non-invasive method of brain stimulation (Transcranial Magnetic Stimulation, TMS).

Conditions:

🦠 Cyclic Vomiting Syndrome

🗓️ Study Start (Actual) 16 May 2022

🗓️ Primary Completion (Estimated) June 2025

✅ Study Completion (Estimated) June 2025

👥 Enrollment (Estimated) 110

🔬 Study Type INTERVENTIONAL

📊 Phase NA

Locations:

📍 Pittsburgh, Pennsylvania, United States

📋 Eligibility Criteria

Description

Inclusion Criteria:

* diagnosis of CVS

Exclusion Criteria:

* history of CVS (for healthy control population only)
* psychosis or altered cognitive status
* history of head injury, metal in the skull, stroke, or a history of seizures
* implantable devices, such as a pacemaker or nerve stimulator
* current use of the following medications or use of substances which are known to lower the seizure threshold: clozapine (Clozaril), chlorpromazine (Thorazine), amphetamines or methamphetamine, Ecstasy, Ketamine, Angel Dust/PCP, cocaine, or 3 or more alcoholic drinks per day
* pregnancy

Ages Eligible for Study: 18 Years to 60 Years (ADULT)

Sexes Eligible for Study: ALL

Accepts Healthy Volunteers: Yes

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

First Submitted 15 February 2022
First Submitted that Met QC Criteria 15 February 2022
First Posted 25 February 2022

Study Record Updates

Last Update Submitted that Met QC Criteria 12 April 2024
Last Update Posted 15 April 2024
Last Verified April 2024