Inclusion Criteria:

• * Patients referred with CTED and/or CTEPH defined as:
• 1. Mean pulmonary arterial pressure (mPAP) \> 20 mmHg at rest with pulmonary vascular resistance (PVR) \> 2 Wood units (WU); or if mPAP ≤ 20 mmHg or PVR ≤ 2 WU at rest, have exercise limitations from chronic thromboembolic pulmonary disease (CTEPD) without pulmonary hypertension (PH)
• 2. Radiologic finding of chronic thromboembolic disease, including abnormal ventilation perfusion scan, pulmonary angiogram, computer tomographic pulmonary angiogram, or magnetic resonance pulmonary angiogram
• 3. Post-embolic exercise intolerance and evidence of chronic thromboembolic disease in the absence of resting pulmonary hypertension
• * Treatment with anticoagulation for ≥ 3 months before diagnosis of CTEPH or CTEPD without PH
• * Age ≥ 18 years

Exclusion Criteria:

• * Main cause of PH other than World Health Organization (WHO) group 4 (CTEPH)
• * Patient's refusal to participate in clinical research and/or receive intervention