Childhood Trauma, Exercise, and Cognition
This study aims to identify and compare the effects of acute and chronic exercise interventions on cognition in middle-aged adults with cognitive complaints and a history of abuse or neglect in childhood. Each participant will be enrolled in the study for up to 78 days, in five parts following verification that the participant meets criteria to be included in the study: 1) initial assessment; 2) first acute exercise condition in lab, symptom measures, and neuropsychological testing; 3) second acute exercise condition in lab, symptom measures, and neuropsychological testing; and 4) 9-week exercise intervention or activity as usual outside of lab, with interview, symptom measures, and neuropsychological testing at three-week intervals.
Conditions:
🦠 Adverse Childhood Experiences
🗓️ Study Start (Actual) 27 November 2023
🗓️ Primary Completion (Estimated) 4 December 2024
✅ Study Completion (Estimated) 4 December 2024
👥 Enrollment (Estimated) 34
🔬 Study Type INTERVENTIONAL
📊 Phase NA
Locations:
📍 Austin, Texas, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • * between 40 and 60 years of age
    • * history of child abuse or neglect
    • * have a complaint about memory, attention, or executive function
    • * native or fluent English speaker
    • * normal or corrected to normal vision and hearing
    • * medically healthy

    Exclusion Criteria:

    • * Score indicating a history of moderate-intensity activity, hard-intensity activity, or very-hard intensity activity on the Stanford Brief Activity Survey
    • * current excessive alcohol or other substance use
    • * eating disorder, bipolar disorder, schizophrenia spectrum disorders, or those judged to be an immediate suicide risk based on having an active plan with intent
    • * autism spectrum disorder, attention-deficit/hyperactivity disorder (ADHD), or other neurodevelopmental disorder
    • * neurocognitive disorder, or illnesses or history of neurological events known to cause neurocognitive disorders (e.g., traumatic brain injury, status epilepticus, stroke)
    • * reported chest pain or dizziness during exercise; any endorsed and not controlled medical condition that could make exercise contraindicated, including hypertension; heart disease; heart failure; hear rhythm disorders; heart valve disease; metabolic conditions; chronic obstructive pulmonary disease; pulmonary hypertension; cystic fibrosis; asthma; and bone, joint, or soft tissue problems
    • * pregnancy, major medical disorders such as cancer, or any other condition believed to put a participant at risk
Ages Eligible for Study: 40 Years to 60 Years (ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: Yes

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 3 July 2023
  • First Submitted that Met QC Criteria 23 July 2023
  • First Posted 2 August 2023

Study Record Updates

  • Last Update Submitted that Met QC Criteria 27 November 2023
  • Last Update Posted 1 December 2023
  • Last Verified November 2023