Description
Inclusion Criteria:
- * Screening or Visit 1 Reactive Hyperemia Index (RHI; EndoPAT 2000) \< 2.0
- * Subject is willing and able to comply with the study protocols.
- * Subject is willing to participate in all study procedures
- * BMI 25.0 - 35 kg/m2
Exclusion Criteria:
- * BMI ≥ 35 kg/m2
- * Indivduals that weight less than a 110 lbs
- * Donation of blood within the previous 30 days
- * Visit 1 Reactive Hyperemia Index (RHI; EndoPAT 2000) ≥ 2.0
- * 1 ug/ml and 3 ug/ml collagen screening maximal platelet aggregatory response of \< 65%.
- * Platelet counts \< 150,000 / ul
- * Anemia, which includes self report, or a screening hemoglobin and hematocrit that is less than the normal reference range or as diagnosed by study physician upon review of complete blood cell count reports.
- * Dislike or allergy for nuts, cocoa or grape products
- * Self-reported use of daily anticoagulation agents including aspirin, NSAIDs
- * Vegan, Vegetarians, food faddists or those consuming a non-traditional diet
- * Fruit consumption ≥ 3 cups/day
- * Vegetable consumption ≥ 4 cups/day
- * Nut intake ≥ 2 servings/ week
- * Coffee/tea ≥ 3 cups/day
- * Dark chocolate ≥ 3 oz/day
- * Self-reported restriction of physical activity due to a chronic health condition
- * Self-reported chronic/routine high intensity exercise
- * Self-reported diabetes
- * Blood pressure ≥ 140/90 mm Hg
- * Self-reported renal or liver disease
- * Self-reported heart disease, which includes cardiovascular events and stroke
- * Peripheral artery disease, Raynaud's syndrome
- * Inability to properly place or wear the PAT probes or abnormal measurements on pre- screening PAT
- * Self-reported cancer within past 5 years
- * Self-reported malabsorption
- * Currently taking prescription drugs or supplements.
- * Supplement use or unwillingness to stop any supplement use, including herbal, plant or botanical, fish oil, oil supplements a month prior to study enrollment.
- * Indications of substance or alcohol abuse within the last 3 years
- * smoking, vaping, cannabis use
- * Current enrollee in a clinical research study.
Ages Eligible for Study:
30 Years to 50 Years (ADULT)
Sexes Eligible for Study: MALE
Accepts Healthy Volunteers:
Yes