Description
Inclusion Criteria:
- 1. Equal to or greater than 12 months and up tp 60 months post kidney transplant
- 2. Estimated glomerular filtration rate (eGFR) equal to or greater than 30ml/min/1.73m squared at screening
- 3. Standard immunosuppression, including calcineurin inhibitor, Mycophenolate Mofetil or Sodium and a glucocorticoid
- 4. Able to provide written consent -
Exclusion Criteria:
- 1. Type I diabetes
- 2. Any other solid organ transplant
- 3. Hemoglobin A1c greater than 12 %
- 4. SGLT2i use at the time of enrollment
- 5. Prior SGLT2i allergy or intolerance
- 6. Pregnant or nursing at the time of enrollment
- 7. History of antibody medicated rejection (AMR) or a Banff score greater than 2B for acute cellular rejection (ACR)
- 8. Active anticoagulant use other than aspirin 81 mg for primary prevention of cardiovascular disease
- 9. Known positive donor-specific antibodies prior to enrollment
- 10. Uncircumcised men
- 11. Greater than 2 urinary tract infections (UTI) over the 12 months prior to enrollment
- 12. Any genital infections over the 12 months prior to enrollment -
Ages Eligible for Study:
18 Years to N/A (ADULT, OLDER_ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
No