Inclusion Criteria:

• 1. Male or female 21 to 80 years of age
• 2. Canadian Cardiovascular Society (CCS) class III or IV chronic refractory angina.
• 3. Lack of control of angina symptoms despite maximum tolerated doses of anti-angina drugs.
• 4. Evidence of inducible myocardial ischemia on baseline stress testing
• 5. Obstructive coronary disease unsuitable for conventional revascularization
• 6. Experience angina episodes at a minimum of 7 angina episodes per week (during a 4-week screening period).
• 7. Able to complete an exercise tolerance test on the treadmill
• 8. Left ventricular ejection fraction of greater than or equal to 40% as measured by echocardiography.
• 9. Qualification of a pre-procedure screening of bone-marrow aspiration
• Exclusion Criteria
• Other cardiac or vascular system or other health-related criteria which may be seen in a patient's history and physical examination.