Description
Inclusion Criteria:
- 1. Women without signs and symptoms of myocardial ischemia (chest pain, abnormal stress testing, abnormal noninvasive testing).
- 2. No cardiac risk factors by Framingham/NCEP criteria, age and BMI matched to the Cardiac Syndrome X population, and a normal exercise stress test.
Exclusion Criteria:
- 1. Contraindications to CMR testing (metal devices in chest, claustrophobia, known angioedema).
- 2. Contraindication to Adenosine or Lexiscan (regadenoson) including heart block (second and third degree) and sinus node disease, significant COPD/asthma, or systemic hypotension (\<90 mmHg).
- 3. Contraindication to Dobutamine including severe systemic hypertension (≥ 220/120 mmHg), unstable angina, significant aortic valve stenosis, complex cardiac arrhythmia including uncontrolled atrial fibrillation, hypertrophic obstructive cardiomyopathy, myocarditis, endocarditis, pericarditis, or uncontrolled congestive heart failure.
- 4. Contraindication to Gadolinium (renal impairment).
- 5. Any renal disease.
- 6. Pregnant and lactating women.
- 7. Inability to perform exercise, eg. orthopedic limitations.
- 8. Allergy to animal dander.
Ages Eligible for Study:
35 Years to 65 Years (ADULT, OLDER_ADULT)
Sexes Eligible for Study: FEMALE
Accepts Healthy Volunteers:
Yes