Inclusion Criteria:

• To be eligible to participate in this study, an individual must meet all of the following criteria:
• 1. Aged \>=2 years
• 2. Have a documented primary care provider near residence
• 3. Fluency in English (applicable to participant or caregiver who will be answering questionnaires)
• 4. Clinical diagnosis of AD, as defined by Hanifin and Rajka criteria, that has been present for \>=3 months before the screening visit
• * Major Criteria: Must have \>=3 basic features:
• * Pruritus
• * Typical morphology and distribution (flexural lichenification in adults, facial and extensor eruptions in infants and children)
• * Chronic or chronically relapsing dermatitis
• * Personal or family history of atopy (asthma, allergic rhinitis, AD)
• * Minor Criteria: Must have \>=3 minor features:
• * Xerosis
• * Ichthyosis/palmar hyperlinearity, keratosis pilaris
• * Immediate (type 1) skin-test reactivity
• * Raised serum IgE
• * Early age of onset
• * Tendency toward cutaneous infections (especially Staphylococcus aureus and herpes simplex), impaired cell-mediated immunity
• * Tendency toward non-specific hand or foot dermatitis
• * Nipple eczema
• * Cheilitis
• * Recurrent conjunctivitis
• * Dennie-Morgan infraorbital fold
• * Keratoconus
• * Anterior subcapsular cataracts
• * Orbital darkening
• * Facial pallor, facial erythema
• * Pityriasis alba
• * Anterior neck folds
• * Itch when sweating
• * Intolerance to wool and lipid solvents
• * Perifollicular accentuation
• * Food intolerance
• * Course influenced by environmental or emotional factors
• * White dermographism, delayed blanch
• 5. EASI \>5 and an IGA\>=1 at time of enrollment.
• 6. Sexually active participants of childbearing potential must agree to use adequate methods of contraception from the screening visit continuously until 30 days after stopping treatment with the investigational product. Childbearing potential is defined for children as participants who have begun menstruating and for adults as participants who are not surgically sterile (hysterectomy and/or tubal ligation) or menopausal (age \>=45 years plus no menses for 12 consecutive months without an alternative medical cause). Adequate contraception methods include: a barrier method (eg, condom use), oral contraceptive pill, hormonal patch or ring, hormonal injection, parenteral hormonal implant, or an intrauterine device.
• 7. Participants and parents/legal guardians (for minor participants) are willing and able to comply with all study visits and/or study-related procedures.
• 8. Participants/parents/guardians must have the ability to provide informed consent/assent as applicable.
• 9. Willingness to perform visits virtually.

Exclusion Criteria:

• 1. Previous treatment of AD:
• * Within 4 weeks prior to the baseline visit with any of the following:
• * Immunosuppressive or immunomodulating systemic drugs such as systemic corticosteroids, azathioprine, methotrexate, cyclosporine
• * Phototherapy or photochemotherapy for AD
• * Within 12 weeks prior to the baseline visit with any of the following having been newly initiated:
• * Topical steroids or topical calcineurin inhibitors
• * Janus kinase (JAK) inhibitors (oral or topical)
• * Dupilumab or any other biologic agent
• * Topical PDE4 inhibitor
• * Emollients containing ceramides, hyaluronic acid, urea or filaggrin degradation products.
• * Bleach baths
• 2. Active infection (chronic or acute) requiring treatment with systemic antibiotics, antivirals, or antifungals within 2 weeks before the baseline visit.
• 3. Superficial skin infection requiring topical treatment within 1 week of baseline visit.
• 4. Known or suspected history of immunosuppression or immunodeficiency.
• 5. Existence of indwelling central line.
• 6. Co-habitation with someone that has a known or suspected history of immunosuppression or immunodeficiency or has a central line.
• 7. Any clinically significant laboratory, history, or exam findings that, in the investigator s opinion, would suggest an increased risk to the participant.
• 8. Self-reported pregnancy or breastfeeding.
• 9. Menstruating females who have not menstruated within 6 weeks prior to screening. Participants who have an intrauterine device or implanted long-term contraceptive agent that prevents them from menstruating regularly will not be excluded.