Bronchial Mapping (GCC 1635)

RECRUITING

I'm interested ...!!

In order to better understand radiation-induced lung toxicity, the investigator proposes a novel functional avoidance approach that incorporates central as well as peripheral BSS segments in the treatment planning process in order to quantify and account for their respective radiosensitivities. Specifically, the investigator proposes a systematic study that involves acquiring pre- and post-SAbR high-resolution CT and SPECT V/Q scans from lung cancer patients who receive radiotherapy, followed by auto-segmentation of the BSS elements using virtual bronchoscopy.

Conditions:

🦠 Thoracic Cancer

🗓️ Study Start (Actual) 1 June 2017

🗓️ Primary Completion (Estimated) December 2025

✅ Study Completion (Estimated) December 2027

👥 Enrollment (Estimated) 40

🔬 Study Type OBSERVATIONAL

📊 Phase N/A

Locations:

📍 Baltimore, Maryland, United States

📋 Eligibility Criteria

Description

Inclusion Criteria:

* Patients with primary or metastatic lung lesions to be treated using stereotactic ablative radiotherapy (There is no limitation on the location or number of lesions for this study) OR Conventionally fractionated RT patients with primary or metastatic lung lesions
* Age ≥ 18 years. No gender or ethnic restrictions.
* Performance status ECOG ≥ 3
* Ability to hold breath for \~20 seconds
* Ability to understand and the willingness to sign a written informed consent.
* Any types and amounts of prior therapy will be allowed for this study.
* Maximum PTV dimension ≤ 70 mm

Exclusion Criteria:

* Children (age \<18 years).
* Women who are pregnant, nursing, or trying to get pregnant.
* ECOG performance status \< 3

Ages Eligible for Study: 18 Years to 80 Years (ADULT, OLDER_ADULT)

Sexes Eligible for Study: ALL

Accepts Healthy Volunteers: No

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

First Submitted 8 April 2016
First Submitted that Met QC Criteria 15 April 2016
First Posted 20 April 2016

Study Record Updates

Last Update Submitted that Met QC Criteria 6 May 2024
Last Update Posted 7 May 2024
Last Verified May 2024