Brain Connections for Arm Movement After Stroke
The purpose of this study is to use Transcranial Magnetic Stimulation (TMS) while subjects are making reaching movements in a robotic arm device in order to discover how different brain areas control movement before and after stroke and when these brain areas are most sensitive to TMS.
Conditions:
🦠 Stroke 🦠 Brain Disease 🦠 Central Nervous System Diseases 🦠 Nervous System Diseases 🦠 Cardiovascular Diseases
🗓️ Study Start (Actual) 10 January 2020
🗓️ Primary Completion (Estimated) 1 June 2025
✅ Study Completion (Estimated) 1 June 2026
👥 Enrollment (Estimated) 17
🔬 Study Type INTERVENTIONAL
📊 Phase NA
Locations:
📍 Pittsburgh, Pennsylvania, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • Inclusion Criteria (control participants):
    • * Be 45-90 years of age
    • * Have adequate language and neurocognitive function to participate in training and testing
    • * Be medically stable to participate in the study
    • * Be English speaking
    • Inclusion Criteria (participants with stroke):
    • * Be 45-90 years of age
    • * Clinically defined, unilateral, hemiparetic stroke with radiologic exclusion of other possible diagnosis
    • * Stroke onset at least 6 months before enrollment
    • * Subcortical stroke (ex: internal capsule, deep white matter of posterior frontal lobe)
    • * Present with mild to moderate arm dysfunction
    • * Be medically stable to participate in the study
    • * Be English speaking

    Exclusion Criteria:

    • (for both groups)
    • * Unable to give informed consent
    • * Have a serious complicating medical illness that would preclude participation
    • * Contractures or orthopedic problems limiting range of joint motion in the potential study arm or other impairments that would interfere with the study activities
    • * Visual loss such that the subject would not be able to see the test patterns on the robot computer monitor
    • * Unable to comply with requirements of the study
    • * Enrollment in another greater-than-minimal risk study
    • * Presence of medical condition or implant that prevents safe administration of TMS or MRI
    • * Pregnancy
Ages Eligible for Study: 45 Years to 90 Years (ADULT, OLDER_ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: Yes

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 21 January 2020
  • First Submitted that Met QC Criteria 24 February 2020
  • First Posted 27 February 2020

Study Record Updates

  • Last Update Submitted that Met QC Criteria 11 July 2023
  • Last Update Posted 13 July 2023
  • Last Verified July 2023