Blood Flow Regulation and Neuromuscular Function Post-Stroke

RECRUITING

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The muscles of stroke survivors can fatigue faster compared to muscles in people who have not had a stroke, which can limit how long a person with stroke can perform tasks such as walking. This study will examine how blood flow is regulated to the exercising leg muscle post-stroke, because if the muscle does not receive enough blood flow it will become fatigued. Finally, the investigators will use a safe and simple non-invasive intervention called ischemic conditioning, which has known effects to improve blood flow to exercising muscle and determine the effects on muscle fatigue.

Conditions:

🦠 Stroke

🗓️ Study Start (Actual) 11 January 2024

🗓️ Primary Completion (Estimated) 30 June 2028

✅ Study Completion (Estimated) 30 June 2028

👥 Enrollment (Estimated) 40

🔬 Study Type INTERVENTIONAL

📊 Phase NA

Locations:

📍 Milwaukee, Wisconsin, United States

📋 Eligibility Criteria

Description

Inclusion Criteria:

* Be between 18-85 years of age
* Able to give informed consent
* ≥6 months post diagnosis of unilateral cortical or sub-cortical stroke
* English speaking

Exclusion Criteria:

* History of blood clots in the extremities or any condition in which compression of the thigh or transient ischemia is contraindicated (e.g. wounds in the leg)
* Chronic pain syndrome
* Low back or hip pain that interferes with lower extremity motor testing
* History of head trauma
* Comorbid neurological disorder
* Peripheral vascular disease
* Myocardial infarction in the previous year
* Inability to follow 2 step commands
* Condition where fatiguing contractions or resisted leg contractions are contraindicated
* Resting SBP ≥160 mmHg or DBP ≥ 110 mmHg
* Pregnancy or breastfeeding.

Ages Eligible for Study: 18 Years to 85 Years (ADULT, OLDER_ADULT)

Sexes Eligible for Study: ALL

Accepts Healthy Volunteers: No

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

First Submitted 30 August 2023
First Submitted that Met QC Criteria 6 September 2023
First Posted 7 September 2023

Study Record Updates

Last Update Submitted that Met QC Criteria 30 May 2024
Last Update Posted 31 May 2024
Last Verified May 2024