Description
Inclusion Criteria:
- 1. Provision of signed and dated informed consent form by the parent(s) or guardian(s)
- 2. Non-penetrating TBI
- 3. Admission to study hospital within 24 hours of injury
- 4. Total GCS score ≤ 8 on admission or within first 48 hours after injury (measured using pediatric GCS 1 for children \< 2 years old and standard GCS for older children)
- 5. Age 1 through 12 years
- 6. Able to randomize:
- * Within 24 hours of injury (for patients with GCS ≤ 8 on admission) OR
- * Within 24 hours of deterioration (for patients deteriorating to GCS ≤ 8 within 48 hours of injury)
Exclusion Criteria:
- 1. Motor GCS score of 6
- 2. GCS of 3 with bilaterally fixed and dilated pupils
- 3. Injury thought to be intentionally inflicted by a family member or caregiver.
Ages Eligible for Study:
1 Year to 12 Years (CHILD)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
No