Description
Inclusion Criteria:
- 1. Age 8 ≤ 25 years at time of enrollment.
- 2. Severe systemic sclerosis or systemic lupus erythematosus based on specific criteria
- 3. Adequate organ function status
- 4. No active, untreated infections.
Exclusion Criteria:
- 1. Previous hematopoietic stem cell transplant (HSCT) or solid organ transplant
- 2. Pregnancy
- 3. Ongoing participation in a clinical trial testing an investigational drug or ongoing receipt of disallowed disease modifying anti-rheumatic drugs (DMARD)
- 4. Severe comorbidity that jeopardizes the ability of the subject to tolerate therapy
Ages Eligible for Study:
8 Years to 25 Years (CHILD, ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
No