Antiseptic Effects on the Dental Implant Internal Surface Microbiome
Soldiers operate in environments that are more likely to lead to oral trauma, risking poor dentition which can directly impact military readiness. Dental restoration can often be accomplished via dental implant insertion. Microbiome-associated complications that result in bone loss, including the micro-leakage of bacterial species proliferating in the dental implant internal cavity, frequently lead to implant failure. Reduction in implant bacterial load may result in a shift of the composition of the microbiome in favor of less pathogenic species, potentially improving dental implant success rates, reducing surgical revisions, and associated cost savings. This study aims to determine how disinfectant gel (hydrogen peroxide or chlorhexidine) insertion into dental implant internal cavities affects implant failure rates, bacterial load and microbiome composition.
Conditions:
🦠 Peri-Implantitis 🦠 Peri-implant Mucositis 🦠 Implant Infection 🦠 Dental Implant Failed
🗓️ Study Start (Actual) 28 July 2022
🗓️ Primary Completion (Estimated) November 2023
✅ Study Completion (Estimated) April 2024
👥 Enrollment (Estimated) 150
🔬 Study Type INTERVENTIONAL
📊 Phase EARLY_PHASE1
Locations:
📍 Tacoma, Washington, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • * Active duty military
    • * 18-55 years old
    • * Over 6 months remaining at local duty station

    Exclusion Criteria:

    • * Tobacco user
    • * Medications that affect soft tissue or bone healing
    • * Metabolic disorder that affects soft tissue or bone healing
    • * Active periodontal disease
Ages Eligible for Study: 18 Years to 55 Years (ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 23 August 2021
  • First Submitted that Met QC Criteria 23 August 2021
  • First Posted 27 August 2021

Study Record Updates

  • Last Update Submitted that Met QC Criteria 19 January 2023
  • Last Update Posted 20 January 2023
  • Last Verified January 2023