American Cranberries to Prevent UTIs in Susceptible Women

RECRUITING

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The investigators pre-preliminary study showed that the urine from a portion of study participants had anti-adhesion activity. The investigators propose that UTI susceptible women can be divided into responders and non-responders depending on whether cranberry intake increase anti-adhesion activity of their urine. The overall objectives are to identify gut microbes and anti-adhesive urinary biomarkers which significantly contribute to the anti-adhesion of E. coli.

Conditions:

🦠 Healthy

🗓️ Study Start (Actual) 2 February 2021

🗓️ Primary Completion (Estimated) 20 August 2025

✅ Study Completion (Estimated) 20 August 2025

👥 Enrollment (Estimated) 60

🔬 Study Type INTERVENTIONAL

📊 Phase NA

Locations:

📍 Gainesville, Florida, United States

📋 Eligibility Criteria

Description

Inclusion Criteria:

* Healthy women participants
* BMI 18.5-29.9 kg/m2
* At least 110 pounds in weight

Exclusion Criteria:

* BMI≥ 30 kg/m2
* Pregnancy and breast-feeding
* Smoking, frequent alcohol use
* History of any clinically important disorder that may interfere with interpretation of the results,
* Intake of medication that might influence the outcome of the study

Ages Eligible for Study: 21 Years to 65 Years (ADULT, OLDER_ADULT)

Sexes Eligible for Study: FEMALE

Accepts Healthy Volunteers: Yes

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

First Submitted 15 October 2020
First Submitted that Met QC Criteria 6 November 2020
First Posted 12 November 2020

Study Record Updates

Last Update Submitted that Met QC Criteria 1 December 2023
Last Update Posted 5 December 2023
Last Verified December 2023