Inclusion Criteria:

• * At least 50 years of age.
• * Able to understand written and spoken English.
• * Able to understand and willing to sign an IRB-approved written informed consent document (or that of a legally authorized representative, if applicable for the trauma cohort)

Exclusion Criteria:

• * Inability or unwillingness to complete health questionnaire.
• * History of a recent (\<30 days) acute viral illness.
• * Current cancer diagnosis and currently receiving chemotherapy or undergoing radiation therapy. A prior history of cancer is allowed if the participant completed therapy \> 1 year prior to enrollment; participants with a prior diagnosis of cancer will be asked to sign a release of information for the research team to obtain records regarding their prior cancer treatment.
• * Current use of drugs that cause DNA damage (e.g. Cytoxan, azathioprine, etc.) for the treatment of a non-malignant disease.
• * Vulnerable populations (e.g. prisoners).
• * Known infection with Hepatitis B or C, HTLV, or HIV.
• * Additional exclusion for optional bone marrow aspirate/biopsy substudy:
• * Use of medications for anticoagulation or "blood thinning" including warfarin, low molecular weight heparins (enoxaparin, daltaparin) or direct-acting oral anticoagulants (dabigatran, rivaroxaban, apixaban, edoxaban or betrixaban)
• * allergy to lidocaine or other local anesthetics.