Inclusion Criteria:

• Non-obstructive atherosclerotic coronary artery plaque (stenosis of 0-39% or stenosis of 40-69% with FFR-CT \>0.8) in a major epicardial vessel \> 2 mm in diameter.

Exclusion Criteria:

• 1. coronary/PAD/carotid revascularization or ischemic stroke or TIA within 6 months prior to enrollment
• 2. Valvular heart disease of moderate or worse severity or requiring interventional procedures or surgery
• 3. LVEF \<35% in the past 12 months
• 4. Pulmonary hypertension with PASP\>50 mm Hg in the past 12 months
• 5. Myocarditis or pericarditis in the past 12 months
• 6. Known Cardiomyopathy (hypertrophic, infiltrative, restrictive, dilated, etc.)
• 7. Heart failure NYHA class 3 or 4
• 8. Hospitalization for heart failure in the preceding 6 months
• 9. Life expectancy of \<1 year
• 10. An organ-transplant recipient or if felt to require listing for solid organ transplantation during study status
• 11. Inability to give informed consent
• 12. Active malignancy (except basal cell skin cancer)
• 13. Cirrhosis
• 14. ESRD
• 15. Pregnancy or planning to conceive during the study period
• 16. Known intolerance or perceived contraindication to any of the study drugs during the study period including statins or aspirin if indicated
• 17. eGFR\<30 ml/min/m2
• 18. Inability to receive iodinated contrast for CCTA
• 19. Chronic immunosuppression therapy
• 20. Uncontrolled psychiatric illness