Description
- Inclusion criteria.
- * BMI of 30-38 kg/m2 and weight stable over the previous 6 months.
- * Satisfied with current weight and not planning to lose weight at the time of enrollment (persons with obesity control group) -or- not satisfied with current weight and motivated to lose weight at the time of enrollment (reduced obese groups)
- * No more than 90 min or 3 bouts of planned physical activity/wk.
- * Pass a medical and physical screening performed by the study physician.
- * Reporting a habitual, regular sleep-wake cycle for the month preceding screening that involved going to bed between 2200 and 0100 h and getting up between 0600 and 0900 h with \>7 h and \<9.25 h in bed.
- * Live or work within 45 minutes of the CU-AMC (reduced obese groups only) (exceptions may be made at the discretion of the Study PI on a case by case basis for highly motivated subjects).
- * Own a smartphone (Android or Apple iOS).
- * For Females
- * Not currently pregnant or lactating
- * Not pregnant within the past 6 months
- * Not planning to become pregnant in the next 12 months; sexually active women of childbearing potential may be enrolled if they use a reliable means of contraception
- * Capable and willing to provide informed consent, understand exclusion criteria, and accept the randomized group assignment (reduced obese groups)
- Exclusion criteria.
- * Being considered unsafe to participate as determined by the study physician;
- * Taking medications affecting weight, triglycerides, or energy intake/energy expenditure in the last 3 months;
- * Having abnormal blood chemistry and/or hematology as deemed significant by the study physician;
- * Ever having a history of systemic, psychiatric, neurological disease, or drug and alcohol abuse;
- * History of cardiovascular disease, diabetes, uncontrolled hypertension, untreated thyroid, renal, hepatic diseases, dyslipidemia or any other medical condition affecting weight or lipid metabolism;
- * Score \> 18 on Beck Depression Index (BDI) will require further assessment by the study physician to determine if it is appropriate for the subject to participate in the study;
- * Use of a continuous positive airway pressure (CPAP) device for the treatment of obstructive sleep apnea (OSA). A score of \>10 on the Epworth sleepiness scale or \>5 on the Pittsburgh Sleep Quality Index will require further assessment by the study physician to determine if it is appropriate for the subject to participate in the study;
- * Being positive for human immunodeficiency virus or hepatitis B or C;
- * History of surgical procedure for weight loss at any time (e.g. gastroplasty, gastric bypass, gastrectomy or partial gastrectomy, adjustable banding, gastric sleeve);
- * Being a smoker or having been a smoker in the previous 6 months;
- * Abnormal eating patterns identified by registered dietitian interview (dietary fat\<15%, dietary fat\>45%, dietary protein \>30%);
- * Working night shifts;
- * Night eating syndrome (at least 25% of food intake is consumed after the evening meal and/or at least two episodes of nocturnal eating per week);
- * Traveling \> 2 time zones 2 weeks prior to an inpatient CTRC study visit;
- * Currently participating in any formal weight loss or physical activity programs or clinical trials.
Ages Eligible for Study:
30 Years to 50 Years (ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Yes