ADAPT Study: Assessing Diet, Appetite and Physiology Throughout Weight Loss Study)
Behavioral weight loss programs for obesity can result in weight loss and health benefits. However, behavioral weight loss often stops despite efforts to continue losing weight, this can be called an involuntarily weight loss plateau. This study investigates changes in metabolism and/or the brain that contribute to the occurrence of an involuntary weight loss plateau.
Conditions:
🦠 Obesity
🗓️ Study Start (Actual) 1 October 2023
🗓️ Primary Completion (Estimated) 31 July 2027
✅ Study Completion (Estimated) 31 July 2027
👥 Enrollment (Estimated) 90
🔬 Study Type INTERVENTIONAL
📊 Phase NA
Locations:
📍 Seattle, Washington, United States
📍 Seattle, Washington, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • * BMI 30.0 - 50.0 kg/m2
    • * Able to attend study intervention classes and study visits/assessments
    • * Independently living with access to food preparation facilities

    Exclusion Criteria:

    • * Current smoker or regular use of nicotine containing products and/or cannabis
    • * Heavy alcohol use (≥2 drinks/d for females, ≥3 drinks/d for males) or drug use
    • * Known cognitive impairments or h/o stroke
    • * Type 2 diabetes (known diagnosis or by screening A1c (≥6.5%))
    • * Medical conditions (chronic diseases, cancer, MS) or labs limiting ability to participate
    • * Females: currently pregnant (or 6-months postpartum of full-term pregnancy) and/or current breastfeeding
    • * Use of medications with significant effects on appetite (e.g., weight loss medications, atypical antipsychotics, stimulants) and/or chronic use of anticoagulants
    • * History of bariatric surgery
    • * History of eating disorder
    • * Current participation in a formal weight loss program
    • * Prior or current participation in a research study involving weight loss
    • * Weight-reduced by \>10% within past year
    • * Weight \> 330 pounds (MRI limit)
    • * Allergy or intolerance to or unwillingness to consume study foods provided at visit
    • * MRI contraindication (e.g., implanted metal, claustrophobia)
    • * Do not have a phone compatible with activity tracker or access to videoconferencing platform that will be used for the dietary intervention or other appropriate technology needed to complete study procedures
    • * Any condition(s) found by the study team and confirmed with the PI(s) that make it unsafe to participate
Ages Eligible for Study: 18 Years to 60 Years (ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: Yes

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 13 November 2023
  • First Submitted that Met QC Criteria 7 December 2023
  • First Posted 18 December 2023

Study Record Updates

  • Last Update Submitted that Met QC Criteria 5 June 2024
  • Last Update Posted 7 June 2024
  • Last Verified June 2024