RECRUITING
I'm interested ...!!
A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial)
The purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta.
Conditions:
🦠 Coarctation of Aorta 🦠 High Blood Pressure
🗓️ Study Start (Actual) 1 April 2024
🗓️ Primary Completion (Estimated) 1 June 2028
✅ Study Completion (Estimated) 1 June 2028
👥 Enrollment (Estimated) 120
🔬 Study Type INTERVENTIONAL
📊 Phase PHASE3
Locations:
📍 Rochester, Minnesota, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • * B/S1 hypertension
    • * SBP 100-139 average based on 3 office measurements.
    • * Age 18 or Older
    • * Previous COA Repair

    Exclusion Criteria:

    • * Currently on beta blocker (BB) therapy
    • * Pregnancy/lactating
    • * eGFR\<30
    • * Hyperkalemia (serum potassium \>5.5mmol/L)
    • * Severe Aortic or Mitral valve stenosis or regurgitation
    • * Epicardial CAD diagnosis
    • * Received antihypertensive medications within the past year
Ages Eligible for Study: 18 Years to N/A (ADULT, OLDER_ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 21 November 2023
  • First Submitted that Met QC Criteria 21 November 2023
  • First Posted 29 November 2023

Study Record Updates

  • Last Update Submitted that Met QC Criteria 25 July 2024
  • Last Update Posted 29 July 2024
  • Last Verified July 2024
I'm interested ...!!