Inclusion Criteria:

• * Has histologically or cytologically confirmed diagnosis of renal cell carcinoma (RCC) with clear cell or papillary histology.
• * Has intermediate-high-risk, high-risk, or M1 no evidence of disease (NED) RCC as defined by the following pathological tumor-node metastasis and tumor grading:
• * Intermediate-high-risk RCC: pT2 Gr4, N0, M0; pT3 Gr3/4, N0, M0
• * High-risk RCC: pT4, N0, M0; pT any stage, N1, M0
• * M1 NED RCC participants who present not only with the primary kidney tumor, but also solid, isolated, soft tissue metastases that can be completely resected at 1 of the following: the time of nephrectomy (synchronous), or ≤2 years from nephrectomy (metachronous)
• * Has undergone complete resection of the primary tumor (partial or radical nephrectomy) and complete resection of solid, isolated, soft tissue metastatic lesion(s) in M1 NED participants.
• * Must have undergone a nephrectomy and/or metastasectomy ≤12 weeks prior to randomization and recovered from surgery and any post-operative complications before randomization.
• * Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 within 7 days before randomization.

Exclusion Criteria:

• * Has had a major surgery other than nephrectomy plus resection of preexisting metastases for M1 NED participants, within 4 weeks prior to randomization.
• * Has residual thrombus post nephrectomy in the vena renalis or vena cava.
• * Received prior systemic anticancer therapy including investigational agents within 4 weeks before randomization.
• * Received prior radiotherapy within 2 weeks of start of study intervention, or radiation-related toxicities, requiring corticosteroids.
• * Received a live or live-attenuated vaccine within 30 days before the first dose of study intervention. Administration of killed vaccines is allowed.
• * Received prior treatment with a cancer vaccine.
• * Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy.
• * Has a known additional malignancy that is progressing or has required active treatment within the past 3 years.
• * Has a history of brain or bone metastatic lesions.
• * Has severe hypersensitivity to study medication or any of the substances used to prepare the study medication.
• * Has an active autoimmune disease that has required systemic treatment in the past 2 years.
• * Has a history of (noninfectious) pneumonitis/interstitial lung disease that required steroids or has current pneumonitis/interstitial lung disease.
• * Has an active infection requiring systemic therapy.
• * History of allogeneic tissue/solid organ transplant.
• * Has not adequately recovered from major surgery or has ongoing surgical complications.