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A Neurobiological Model of Anhedonia
The purpose of this research study is to better understand anhedonia in Major Depressive Disorder by investigating the reward-related neural and inflammatory correlates.
Conditions:
🦠 Anhedonia 🦠 Depression
🗓️ Study Start (Actual) 19 February 2020
🗓️ Primary Completion (Estimated) 30 July 2024
✅ Study Completion (Estimated) 30 July 2025
👥 Enrollment (Estimated) 60
🔬 Study Type OBSERVATIONAL
📊 Phase N/A
Locations:
📍 Hershey, Pennsylvania, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • * Current diagnosis of MDD based on the MINI International Neuropsychiatric Interview (MINI)
    • * For treatment resistant depression participants: unsuccessful treatment with at least 2 types or doses of antidepressant medication treatment
    • * Right-handed
    • * Capacity for informed consent
    • * Score a 9 or higher on the MADRS

    Exclusion Criteria:

    • * Comorbid Bipolar Disorder
    • * Substance use disorder in the last 12 months
    • * Schizophrenia, and other psychotic disorders
    • * Comorbid illness such as endocrinological illness (e.g. Cushing's disease) rheumatologic illness (e.g., systemic Lupus erythematosus, current treatment with glucocorticoids), and autoimmune diseases (e.g. psoriasis)
    • * Pregnancy
    • * Daily NSAID or aspirin use and any metallic implant
    • * Visual/Hearing Impairments that would keep participant from being able to complete tasks
Ages Eligible for Study: 18 Years to 65 Years (ADULT, OLDER_ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: Yes

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 31 October 2022
  • First Submitted that Met QC Criteria 17 November 2022
  • First Posted 29 November 2022

Study Record Updates

  • Last Update Submitted that Met QC Criteria 21 September 2023
  • Last Update Posted 25 September 2023
  • Last Verified September 2023
I'm interested ...!!